Abstract | BACKGROUND: METHODS: This study analyzed VDR, RXR and PPARγ by immunohistochemistry in BRCA1 associated (n = 38) and sporadic breast cancer (n = 79). Receptors were quantified by applying an established scoring system (IR-score) and were tested for association with clinico-pathological variables. RESULTS: VDR, RXR and PPARγ were detected in over 90% of triple negative BRCA1 mut breast cancer and were significantly (VDR: p < 0.001, RXR: p = 0.010, PPARγ: p < 0.001) overexpressed in BRCA1 mutated as compared to sporadic cancer cases. VDR and RXR positivity predicted prolonged overall survival only in BRCA1 mutated cases while such association was not observed in sporadic breast cancer. CONCLUSIONS: In conclusion, this is the first study to describe VDR, RXR and PPARγ in BRCA1 mutated breast cancer. Based on the data presented here these receptors may be hypothesized to potentially evolve as interesting markers or even targets in hereditary breast cancer. However, independent studies are indispensable thus to confirm this hypothesis.
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Authors | Sabine Heublein, Doris Mayr, Alfons Meindl, Alexandra Kircher, Udo Jeschke, Nina Ditsch |
Journal | Journal of experimental & clinical cancer research : CR
(J Exp Clin Cancer Res)
Vol. 36
Issue 1
Pg. 57
(04 20 2017)
ISSN: 1756-9966 [Electronic] England |
PMID | 28427429
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- BRCA1 Protein
- BRCA1 protein, human
- PPAR gamma
- Receptors, Calcitriol
- Retinoid X Receptors
- VDR protein, human
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Topics |
- Adult
- Aged
- BRCA1 Protein
(genetics)
- Female
- Gene Expression Regulation, Neoplastic
- Humans
- Middle Aged
- Mutation
- PPAR gamma
(metabolism)
- Prognosis
- Receptors, Calcitriol
(metabolism)
- Retinoid X Receptors
(metabolism)
- Survival Analysis
- Triple Negative Breast Neoplasms
(genetics, metabolism)
- Up-Regulation
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