[Receptor-dependent regulation of the concentration of Ca2+ in the cytoplasm of thrombocytes in hypertensive patients].

Abstract

Platelet activation factor (PAF)-, ADP and vasopressin-induced increments of platelet Ca2+ concentration were measured by quin-2 in 64 patients with essential hypertension and 16 normal donors. Basal concentration of free Ca2+ was 87 +/- 4 nM in donors, 106 +/- 5 nM in patients with labile hypertension (LH) and 122 +/- 6 nM in those with stable hypertension (SH) (p less than 0.01). PAF, ADP and vasopressin, added to platelets, increased [Ca]in by 448 +/- 58, 397 +/- 66, and 277 +/- 50 nM, respectively, in the donors, by 473 +/- 57, 479 +/- 54 and 195 +/- 32 nM, in LH patients, and by 607 +/- 85, 584 +/- 73 and 245 +/- 41 nM in SH patients. There were no significant variations between the three samples, using the ANOVA test. In 20 patients, whose both parents had essential hypertension, [Ca]in increment was 738 +/- 8 nM for PAF, 682 +/- 90 nM for ADP, and 320 +/- 61 nM for vasopressin. In 19 patients, who admitted to no essential hypertension in the family, these parameters were significantly lower: 310 +/- 40 nM for PAF, 389 +/- 61 nM for ADP, and 147 +/- 26 nM for vasopressin. The demonstrated changes may be making an important contribution to the maintenance of elevated vascular tone and provide an evidence in favor of a genetically-predetermined EH variety.

• Authors: I K Shkhvatsabaia, A N Kravchenko, P V Avdonin, M Iu Men'shikov, A A Nekrasova
• Journal: Kardiologiia (Kardiologiia) Vol. 28 Issue 5 Pg. 72-7 (May 1988) ISSN: 0022-9040 [Print] Russia (Federation)
• Vernacular Title: Retseptorzavisimaia reguliatsiia kontsentratsii Ca2+ v tsitoplazme trombotsitov bol'nykh gipertonicheskoĭ bolezn'iu.
• PMID: 2842537 (Publication Type: English Abstract, Journal Article)

Chemical References

• Platelet Activating Factor
• Receptors, Cell Surface
• Vasopressins
• Adenosine Diphosphate
• Calcium

Topics

• Adenosine Diphosphate (pharmacology)
• Adult
• Blood Platelets (drug effects, metabolism)
• Calcium (blood)
• Cytoplasm (drug effects, metabolism)
• Humans
• Hypertension (blood, genetics)
• Male
• Middle Aged
• Platelet Activating Factor (pharmacology)
• Receptors, Cell Surface (drug effects, physiology)
• Vasopressins (pharmacology)