Inhibition of ovulation, steroidogenesis and collagenolytic activity in rabbits by sulpiride-induced hyperprolactinaemia.

Abstract

Ovulation induced by hCG in rabbits was reduced significantly (P less than 0.005) by sulpiride-induced hyperprolactinaemia. The pre- and post-ovulatory increases in peripheral and ovarian venous progesterone (but not oestradiol or testosterone) were suppressed in the treated animals. The condition of hyperprolactinaemia also prevented the usual changes in 2,4-dinitrophenyl-Pro-Gln-Gly-Ile-Ala-Gly-Gln-D-Arg-OH peptidase (DNP-peptidase) and alpha-N-benzoyl-DL-Arg-beta-naphthylamide hydrolase (BANA-hydrolase) activities in follicular tissue that had been stimulated by an ovulatory dose of hCG. These results suggest that inhibition of progesterone production and collagenolytic enzyme activity by sulpiride-induced hyperprolactinaemia may be responsible for the ovulatory dysfunction that occurs when a mammal has a high level of circulating prolactin.

• Authors: K C Lin, N Kawamura, H Okamura, T Mori
• Journal: Journal of reproduction and fertility (J Reprod Fertil) Vol. 83 Issue 2 Pg. 611-8 (Jul 1988) ISSN: 0022-4251 [Print] England
• PMID: 2842496 (Publication Type: Journal Article)

Chemical References

• Chorionic Gonadotropin
• Progesterone
• Sulpiride
• Collagen
• Cathepsins
• Cysteine Endopeptidases
• Cathepsin H
• Microbial Collagenase

Topics

• Animals
• Cathepsin H
• Cathepsins (metabolism)
• Chorionic Gonadotropin (pharmacology)
• Collagen (metabolism)
• Cysteine Endopeptidases
• Female
• Hyperprolactinemia (chemically induced, metabolism)
• Microbial Collagenase (metabolism)
• Ovarian Follicle (enzymology)
• Ovulation (drug effects)
• Progesterone (blood)
• Rabbits
• Sulpiride (pharmacology)