Human papillomavirus vaccine efficacy in the prevention of anogenital warts: systematic review and meta-analysis.

Abstract

OBJECTIVE::

To review evidence on the efficacy of HPV vaccines in the prevention of non-cancer lesions (anogenital warts [AGW], recurrent laryngeal papillomatosis and oral papillomatosis).

MATERIALS AND METHODS::

We conducted a systematic review of randomized trials. We performed random effect models and effects were reported as relative risks (RR) and their confidence intervals (95%CI) following both intention to treat (ITT) and per protocol (PP) analyses.

RESULTS::

We included six studies (n=27 078). One study was rated as high risk of bias. One study could not be included in the meta-analysis because it provided combined results. We found that quadrivalent vaccine reduced the risk of AGW by 62% (RR: 0.38, 95%CI:0.32-0.45, I2:0%) in the ITT analysis and by 95% (RR: 0.05, 95%CI:0.01-0.25, I2:66%) in the PP analysis. Subgroup analyses of studies in women or with low-risk of bias provided similar results.

CONCLUSION::

HPV quadrivalent vaccine is efficacious in preventing AGW in men and women.

• Authors: Romina A Tejada, Kris G Vargas, Vicente Benites-Zapata, Edward Mezones-Holguín, Rafael Bolaños-Díaz, Adrián V Hernandez
• Journal: Salud publica de Mexico (Salud Publica Mex) 2017 Jan-Feb Vol. 59 Issue 1 Pg. 84-94 ISSN: 1606-7916 [Electronic] Mexico
• PMID: 28423114 (Publication Type: Journal Article, Meta-Analysis, Review, Systematic Review)

Chemical References

• Papillomavirus Vaccines

Topics

• Anus Diseases (prevention & control, virology)
• Condylomata Acuminata (prevention & control)
• Female
• Genital Diseases, Female (prevention & control, virology)
• Genital Diseases, Male (prevention & control, virology)
• Humans
• Male
• Papillomavirus Infections (prevention & control)
• Papillomavirus Vaccines
• Randomized Controlled Trials as Topic