Kallikrein-like esteroprotease activity and kininase activity in submandibular gland from a mutant mouse with human cystic fibrosis like alterations.

Abstract

The submandibular gland of cri/cri and control mice were compared for their activity of glandular kallikrein like esteroprotease and kininase. Esteroprotease activity is significantly reduced in cri/cri mice with respect to control, with an increased kininase activity in cri/cri mice. Since previous work showed an electrolyte abnormality in the salivary glands of this mutant mouse (1) a possible relationship between this alteration with the low activity of cellular esteroprotease and the high kininase activity is suggested.

• Authors: G Dodera Martínez, S B Vila, O L Catanzaro, O H Pivetta
• Journal: Life sciences (Life Sci) Vol. 43 Issue 6 Pg. 533-6 ( 1988) ISSN: 0024-3205 [Print] Netherlands
• PMID: 2841551 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Peptidyl-Dipeptidase A
• Serine Endopeptidases

Topics

• Animals
• Cystic Fibrosis (enzymology)
• Female
• Male
• Mice
• Mice, Inbred DBA
• Mice, Mutant Strains
• Peptidyl-Dipeptidase A (metabolism)
• Serine Endopeptidases (metabolism)
• Sex Characteristics
• Submandibular Gland (enzymology)