ev 22, a new endogenous avian leukosis virus locus found in chickens with spontaneous autoimmune thyroiditis.

Abstract

Chickens of the Obese strain (OS) develop a hereditary spontaneous autoimmune thyroiditis (SAT) which closely resembles human Hashimoto's disease. Analysis of the endogenous viruses harboured by these animals revealed a new endogenous virus (ev22) detected as a 5.5 kb Sac I fragment. Crossbreeding experiments showed that ev22 is vertically transmitted as an autosomal trait not associated with major histocompatibility (MHC) alleles. Preliminary experiments indicate that ev22 does not necessarily cause SAT, however, it may have a modulatory role in the development of the disease.

• Authors: A Ziemiecki, G Krömer, R G Mueller, K Hàla, G Wick
• Journal: Archives of virology (Arch Virol) Vol. 100 Issue 3-4 Pg. 267-71 ( 1988) ISSN: 0304-8608 [Print] Austria
• PMID: 2840875 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• DNA Restriction Enzymes
• endodeoxyribonuclease SacI
• Deoxyribonucleases, Type II Site-Specific

Topics

• Animals
• Avian Leukosis Virus (genetics)
• Chickens
• DNA Restriction Enzymes
• Deoxyribonucleases, Type II Site-Specific
• Female
• Genes, Viral
• Major Histocompatibility Complex
• Male
• Thyroiditis, Autoimmune (genetics, microbiology)