[Nucleotide modification of mitochondrial tRNA and mitochondrial diseases].

Abstract

A high proportion of modified nucleotides has been found in mitochondrial tRNA. Such modification can promote accurate folding of tRNA and its stability, while unmodified mitochondrial tRNA may fold into various 2D-structures with impaired functions. Therefore, modification of mitochondrial tRNA is closely related to mitochondrial diseases. Particularly, positions 9, 34, 37, 54 and 55 of the mitochondrial tRNA are critical for such modification. Mutations at these positions are important cause for mitochondrial dysfunction and have been associated with various mitochondrial diseases.

• Authors: Feng Jiang, Minxin Guan, Ling Xue
• Journal: Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics (Zhonghua Yi Xue Yi Chuan Xue Za Zhi) Vol. 34 Issue 2 Pg. 275-279 (Apr 10 2017) ISSN: 1003-9406 [Print] China
• PMID: 28397236 (Publication Type: Journal Article, Review)

Chemical References

• DNA, Mitochondrial
• RNA, Transfer

Topics

• DNA, Mitochondrial (chemistry, genetics)
• Humans
• Mitochondrial Diseases (genetics)
• Mutation
• Nucleic Acid Conformation
• RNA, Transfer (chemistry, genetics)