Human aldolase A gene: structural organization and expression in tumor cell lines.

Abstract

The structural intron/exon organization of the cloned human aldolase A gene is reported. The gene is composed of twelve exons, including the coding and the 5' and 3' non-coding regions. Four mRNAs, different at the 5' non-coding region, are transcribed from this gene in a tissue-specific manner. The study of the expression of aldolase A gene in normal liver and neoplastic cell lines demonstrated the resurgence of foetal pattern of expression in all tumor liver cell lines and HeLa cells, thus supporting the foetalism theory for this gene system.

• Authors: P Costanzo, P Izzo, A Lupo, E Rippa, G Paolella, F Salvatore
• Journal: The Italian journal of biochemistry (Ital J Biochem) 1988 Jan-Feb Vol. 37 Issue 1 Pg. 8-13 ISSN: 0021-2938 [Print] Italy
• PMID: 2838431 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• RNA, Messenger
• Fructose-Bisphosphate Aldolase

Topics

• Carcinoma, Hepatocellular (enzymology, genetics)
• Exons
• Fructose-Bisphosphate Aldolase (genetics)
• Humans
• Introns
• Liver (analysis)
• Liver Neoplasms
• Nucleic Acid Hybridization
• RNA, Messenger (analysis)
• Tumor Cells, Cultured