Abstract | Background: Methods: Totals of 283 incident GNCA, 96 EGJA and 10 gastric carcinoid cases, and 778 matched controls, were included in our analysis. Gastrin and CCK were measured using specific radioimmunoassays. Odds ratios (OR) and 95% confidence intervals (95% CI) were estimated by multivariable logistic regression with adjustment for all known or suspected confounding factors, including Helicobacter pylori seropositivity. Results: Those with high gastrin (Q4 vs Q1), had an increased risk of GNCA (fully adjusted OR: 1.92; 95% CI: 1.21, 3.05) and gastric carcinoids, though the small number of carcinoid cases meant the fully adjusted model was unstable (age-adjusted continuous model OR: 4.67; 95% CI: 2.67, 8.15). CCK was associated with risk of GNCA only for those in Q3 relative to Q1 (OR: 0.56; 95% CI: 0.33, 0.96), and no significant trend was observed. Conclusions: Our data suggest that high serum concentrations of gastrin may be associated independently with an increased risk of gastric cancer; the role of CCK in cancer risk is less clear.
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Authors | Gwen Murphy, Christian C Abnet, Hyoyoung Choo-Wosoba, Emily Vogtmann, Stephanie J Weinstein, Philip R Taylor, Satu Männistö, Demetrius Albanes, Sanford M Dawsey, Jens F Rehfeld, Neal D Freedman |
Journal | International journal of epidemiology
(Int J Epidemiol)
Vol. 46
Issue 3
Pg. 914-923
(06 01 2017)
ISSN: 1464-3685 [Electronic] England |
PMID | 28369403
(Publication Type: Journal Article)
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Copyright | Published by Oxford University Press on behalf of the International Epidemiological Association 2017. This work is written by US Government employees and is in the public domain in the United States. |
Chemical References |
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Topics |
- Adenocarcinoma
(blood, epidemiology)
- Case-Control Studies
- Cholecystokinin
(blood)
- Esophageal Neoplasms
(blood, epidemiology)
- Finland
(epidemiology)
- Follow-Up Studies
- Gastrins
(blood)
- Helicobacter Infections
(epidemiology)
- Helicobacter pylori
- Humans
- Incidence
- Logistic Models
- Male
- Middle Aged
- Multivariate Analysis
- Prospective Studies
- Risk Factors
- Smokers
- Stomach Neoplasms
(blood, epidemiology)
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