| Abstract |
Pharmacokinetics of a spin-labeled analog of rubomycin ( ruboxyl) was studied. Differences were found in ruboxyl pharmacokinetics in normal and tumor-bearing animals. Most of the drug was excreted within 6 h. The differences in pharmacokinetics of ruboxyl and nitroxyl radical were established. |
| Authors | N P Konovalova, R F Diatchkovskaya, G V Kukushkina, L M Volkova, V N Varfolomeev, L S Dombrovsky, A B Shapiro |
| Journal | Neoplasma
(Neoplasma)
Vol. 35
Issue 2
Pg. 185-90
( 1988)
ISSN: 0028-2685 [Print] Slovakia |
| PMID | 2836742
(Publication Type: Journal Article)
|
| Chemical References |
|
| Topics |
- Animals
- Daunorubicin
(analogs & derivatives, pharmacokinetics, therapeutic use)
- Electron Spin Resonance Spectroscopy
- Liver
(metabolism)
- Mice
- Sarcoma 180
(drug therapy, metabolism)
- Tissue Distribution
|
