Abstract |
The effects of erythrosine (Red 3), rose bengal B (Red 105) and thyroidectomy on the development of thyroid tumor were examined in male Wistar rats treated with N-bis(2-hydroxypropyl)nitrosamine ( DHPN). Red 3 and Red 105 were used at 4% in the basal diet and were administered for 19 weeks from week 2 to 20. Thyroidectomy was performed by resection of the left lobe at week 4. Single injection of DHPN was performed intraperitoneally at 280 mg per 100 g body weight at the beginning of the experiment. Red 3 and Red 105 significantly promoted the development of thyroid tumors in thyroidectomized rats given DHPN, but had no significant effect in non-thyroidectomized rats. The incidence of thyroid tumors was 91% in rats with partial thyroidectomy, Red 3 and DHPN, 100% in rats with partial thyroidectomy, Red 105 and DHPN, and 64% in rats with partial thyroidectomy and DHPN. Serum TSH was 5.5 +/- 3.1 ng/ml in rats with partial thyroidectomy, Red 3 and DHPN, 2.1 +/- 2.2 ng/ml in rats with partial thyroidectomy, Red 105 and DHPN, and 1.5 +/- 0.5 ng/ml in rats with partial thyroidectomy and DHPN.
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Authors | Y Hiasa, M Ohshima, Y Kitahori, N Konishi, T Shimoyama, Y Sakaguchi, H Hashimoto, S Minami, Y Kato |
Journal | Japanese journal of cancer research : Gann
(Jpn J Cancer Res)
Vol. 79
Issue 3
Pg. 314-9
(Mar 1988)
ISSN: 0910-5050 [Print] Japan |
PMID | 2836348
(Publication Type: Journal Article)
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Chemical References |
- Coloring Agents
- Fluoresceins
- Food Coloring Agents
- Nitrosamines
- Triiodothyronine
- Rose Bengal
- Rose Bengal B
- diisopropanolnitrosamine
- Thyrotropin
- Erythrosine
- Thyroxine
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Topics |
- Animals
- Body Weight
(drug effects)
- Coloring Agents
- Erythrosine
(toxicity)
- Fluoresceins
(toxicity)
- Food Coloring Agents
(toxicity)
- Liver
(drug effects)
- Male
- Neoplasms, Experimental
(blood, chemically induced, physiopathology)
- Nitrosamines
- Organ Size
(drug effects)
- Rats
- Rats, Inbred Strains
- Rose Bengal
(analogs & derivatives, toxicity)
- Thyroid Gland
(drug effects)
- Thyroid Neoplasms
(blood, chemically induced, physiopathology)
- Thyroidectomy
- Thyrotropin
(blood)
- Thyroxine
(blood)
- Triiodothyronine
(blood)
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