[The effects of eicosapentaenoic acid ethyl ester (EPA-E) on arterial thrombosis in rabbits and vascular lesions in rats].

Abstract

The effects of highly purified ethyl ester of eicosapentaenoic acid (EPA-E) on ellagic acid-induced thrombus formation in the stenosed femoral artery in rabbits and on the progression of laurate-induced vascular lesions in rats were examined. (1) EPA-E in single administration significantly prevented the thrombus formation induced by ellagic acid in the stenosed femoral artery of rabbits. (2) EPA-E restored the hypercoagulation activity at 5 min and 3 hr after the ellagic acid injection. Platelet aggregability induced by arachidonic acid decreased at 5 min and 3 hr after the ellagic acid injection; EPA-E had little effect on this change. EPA-E showed almost no effect on fibrinolytic activity, blood viscosity and filterability of washed red blood cells after the ellagic acid injection. (3) Moreover, EPA-E in daily administrations showed a significant preventative effect against the laurate-induced vascular lesions in rats. The efficacy of EPA-E on arterial thrombosis and vascular lesions observed in this study suggests that EPA-E is a candidate for the treatment of peripheral circulatory disturbance.

• Authors: M Mizota, Y Katsuki, K Mizuguchi, S Endo, H Miyata, M Kojima, H Kanehiro, M Okada, A Takase, K Serizawa
• Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica (Nihon Yakurigaku Zasshi) Vol. 91 Issue 2 Pg. 81-9 (Feb 1988) ISSN: 0015-5691 [Print] Japan
• PMID: 2836280 (Publication Type: Journal Article)

Chemical References

• Laurates
• Ellagic Acid
• eicosapentaenoic acid ethyl ester
• Eicosapentaenoic Acid

Topics

• Animals
• Eicosapentaenoic Acid (analogs & derivatives, pharmacology)
• Ellagic Acid
• Gangrene (chemically induced, prevention & control)
• Laurates
• Male
• Rabbits
• Rats
• Rats, Inbred Strains
• Thrombosis (chemically induced, prevention & control)