Abstract | BACKGROUND: METHODS: One hundred and one patients with newly diagnosed diffuse large B-cell lymphoma who had planned to receive anthracycline chemotherapy were enrolled. LV apical rotation, basal rotation, twist, torsion, time to peak apical rotation and time to peak basal rotation were measured by 3D-STE at baseline, after the completion of two cycles and four cycles of the regimen, respectively. Apical-basal rotation delay was calculated as the difference between time to basal and time to apical rotation. RESULTS: The results showed that LV apical rotation, basal rotation, twist and torsion declined progressively during the whole procedure (baseline vs. two and four cycles of the regimen, apical rotation: 12.5 ± ± 4.5° vs. 8.8 ± 3.6° vs. 6.0 ± 3.2°; basal rotation: -7.7 ± 3.0° vs. -5.9 ± 2.6° vs. -4.4 ± 2.5°; twist: 20.0 ± 6.4° vs. 14.5 ± 5.1° vs. 9.8 ± 4.5°; torsion: 2.9 ± 0.9°/cm vs. 2.1 ± 0.9°/cm vs. 1.4 ± 0.7°/cm; all p < 0.01). Furthermore, apical-basal rotation delay increased significantly after two cycles as well as after four cycles of the regimen (38.3 ± 67.9 ms vs. 66.7 ± 73.9 ms vs. 92.6 ± 96.9 ms; p < 0.01). CONCLUSIONS: LV twisting function deteriorated in the early stage of anthracycline therapy in patients with lymphoma, which could be detected by 3D-STE sensitively.
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Authors | Feiyan Song, Yu Kang, Chujie Zhang, Yuchen Xu, Jing Shi, Ye Guo, Qunling Zhang, Xianhong Shu, Leilei Cheng |
Journal | Cardiology journal
(Cardiol J)
Vol. 24
Issue 5
Pg. 484-494
( 2017)
ISSN: 1898-018X [Electronic] Poland |
PMID | 28353310
(Publication Type: Journal Article)
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Chemical References |
- Anthracyclines
- Antibiotics, Antineoplastic
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Topics |
- Adult
- Aged
- Anthracyclines
(adverse effects)
- Antibiotics, Antineoplastic
(adverse effects)
- Biomechanical Phenomena
- Cardiotoxicity
- Early Diagnosis
- Echocardiography, Doppler, Pulsed
- Echocardiography, Three-Dimensional
- Female
- Humans
- Lymphoma, Large B-Cell, Diffuse
(drug therapy)
- Male
- Middle Aged
- Observer Variation
- Predictive Value of Tests
- Prospective Studies
- Reproducibility of Results
- Risk Factors
- Time Factors
- Torsion Abnormality
(chemically induced, diagnostic imaging, physiopathology)
- Torsion, Mechanical
- Ventricular Dysfunction, Left
(chemically induced, diagnostic imaging, physiopathology)
- Ventricular Function, Left
(drug effects)
- Young Adult
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