Abstract |
One hundred twenty-one species of edible plants (133 test-parts) were screened against possible anti- tumor promoting activity by an in vitro short-term assay system of inhibition of Epstein-Barr virus (EBV) activation induced by a phorbol-ester promoter, 12-O-hexadecanoylphorbol-13-acetate (HPA). The methanol-extracts (ME) of 14 species of the edible plants strongly inhibited the activation, 7 moderately and 12 weakly inhibited it. On partition of the randomly selected inactive ME (26 species) with ethyl acetate and water, 13 and 2 species were active, more or less, in the ethyl acetate and water soluble part, respectively. Thus, this result suggested that anti- tumor promoters occur in a wide variety of edible plants. The anti- tumor promoting activity in the crude extracts may be enhanced or reduced with co-occurring factors acting additively, synergistically or antagonistically.
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Authors | K Koshimizu, H Ohigashi, H Tokuda, A Kondo, K Yamaguchi |
Journal | Cancer letters
(Cancer Lett)
Vol. 39
Issue 3
Pg. 247-57
(Apr 1988)
ISSN: 0304-3835 [Print] Ireland |
PMID | 2834042
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antineoplastic Agents, Phytogenic
- Phorbol Esters
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Topics |
- Antineoplastic Agents, Phytogenic
(analysis)
- Herpesvirus 4, Human
(drug effects)
- Humans
- Phorbol Esters
- Plants, Edible
(analysis)
- Virus Activation
(drug effects)
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