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Intrahippocampal injections of a specific mu-receptor ligand PL017 produce generalized convulsions in rats.

Abstract
The effects of a selective mu-agonist, [NMe-Phe3-D-Pro4]morphiceptin (PL017), and a selective mu-antagonist, beta-funaltrexamine (beta-FNA), on convulsions and wet dog shakes (WDS) were studied. Electroencephalogram demonstrated that a single injection of PL017 into the ventral hippocampus evoked epileptiform spiking which appeared initially in the ventral hippocampus and spread to the cortical area when the animal developed generalized convulsion. Behavioral studies showed that PL017-induced convulsions and WDS were dose-dependent, and these behavioral changes were blocked by beta-FNA pretreatment. The results indicate that mu-receptors in the hippocampus may play an important role in seizure activities evoked by opioids.
AuthorsP H Lee, J Obie, J S Hong
JournalBrain research (Brain Res) Vol. 441 Issue 1-2 Pg. 381-5 (Feb 16 1988) ISSN: 0006-8993 [Print] Netherlands
PMID2834004 (Publication Type: Journal Article)
Chemical References
  • Convulsants
  • Endorphins
  • Receptors, Opioid
  • Receptors, Opioid, mu
  • morphiceptin, N-Me-Phe(3)-
Topics
  • Animals
  • Cerebral Cortex (drug effects, physiology)
  • Convulsants (pharmacology)
  • Electroencephalography
  • Endorphins (pharmacology)
  • Hippocampus (drug effects, physiology)
  • Male
  • Rats
  • Rats, Inbred F344
  • Receptors, Opioid (drug effects, physiology)
  • Receptors, Opioid, mu
  • Seizures (chemically induced, physiopathology)

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