Does systemic administration of casein phosphopeptides affect orthodontic movement and root resorption in rats?

Abstract

OBJECTIVES:

To assess the potential effects of casein phosphopeptides (CPPs) on orthodontically induced iatrogenic root resorption (OIIRR) and orthodontic teeth movement.

MATERIALS AND METHODS:

Forty Wistar rats (aged 11 weeks) were randomly divided into experimental group (EG; n = 20) that received a diet supplemented with CPP and control group (CG; n = 20) devoid of diet supplement. A 150 g force was applied using nickel titanium (NiTi) coil that was bonded on maxillary incisors and extended unilaterally to a maxillary first molar. At Day 28, animals in both groups were euthanized. Volumetric assessment of root resorption craters and linear measurement of maxillary first molars movement were blindly examined using a micro-computed tomography scan.

RESULTS:

Nine rats were excluded from the experiment due to loss during general anesthesia or appliances' failure. Intra-operator reproducibility was high in both volumetric and linear measurements, 92.8 per cent and 98.5-97.6 per cent, respectively. The results reveal that dietary CPP has statistically insignificant effect on the overall OIIRR and orthodontic movement.

CONCLUSIONS:

CPP seems to have statistically insignificant effect on the volume of OIIRR and orthodontic movement in rats. A long-term study with larger sample size using a different concentration of CPP is required to clarify the dentoalveolar effect of CPP.

• Authors: Lachlan Crowther, Gang Shen, Mohammed Almuzian, Allan Jones, William Walsh, Rema Oliver, Peter Petocz, Nour E Tarraf, M Ali Darendeliler
• Journal: European journal of orthodontics (Eur J Orthod) Vol. 39 Issue 5 Pg. 541-546 (Oct 01 2017) ISSN: 1460-2210 [Electronic] England
• PMID: 28339790 (Publication Type: Journal Article)
• Copyright: © The Author 2017. Published by Oxford University Press on behalf of the European Orthodontic Society. All rights reserved. For permissions, please email: [email protected]

Chemical References

• Alloys
• Caseins
• Dental Alloys
• Phosphopeptides
• nitinol

Topics

• Alloys
• Animals
• Caseins (therapeutic use)
• Dental Alloys
• Dietary Supplements
• Incisor (physiopathology)
• Male
• Molar (physiopathology)
• Phosphopeptides (therapeutic use)
• Rats
• Rats, Wistar
• Reproducibility of Results
• Root Resorption (etiology, prevention & control)
• Tooth Movement Techniques (adverse effects, methods)
• X-Ray Microtomography (methods)