HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Comparative anticonvulsant activity and neurotoxicity of 4-amino-N-(2,6-dimethylphenyl)benzamide and prototype antiepileptic drugs in mice and rats.

Abstract
The anticonvulsant and toxic properties of 4-amino-N-(2,6-dimethylphenyl)benzamide, (ADD 75073), were compared with phenytoin (PHT), phenobarbital (PB), ethosuximide (ESM), and valproate (VPA). These compounds were evaluated in mice and rats using well-standardized anticonvulsant test procedures. The results indicate that ADD 75073 is a very potent anticonvulsant in the maximal electroshock seizure (MES) model. The compound was effective in nontoxic doses following intraperitoneal (i.p.) administration in mice and oral administration in both mice and rats. In mice, the i.p. administration of ADD 75073 resulted in an ED50 value of 2.6 mg/kg as compared with a value of 9.5 mg/kg for phenytoin (PHT) in the same assay. Compound ADD 75073 was ineffective in nontoxic doses against all other seizure models examined in this study, and thus has a pharmacologic profile similar to that of PHT.
AuthorsC R Clark
JournalEpilepsia (Epilepsia) Vol. 29 Issue 2 Pg. 198-203 ( 1988) ISSN: 0013-9580 [Print] United States
PMID2832143 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Anticonvulsants
  • Benzamides
  • Receptors, GABA-A
  • Picrotoxin
  • Ethosuximide
  • Valproic Acid
  • Phenytoin
  • ameltolide
  • Strychnine
  • Phenobarbital
Topics
  • Animals
  • Anticonvulsants (pharmacology, toxicity)
  • Behavior, Animal (drug effects)
  • Benzamides (pharmacology, toxicity)
  • Electroshock
  • Ethosuximide (pharmacology)
  • Lethal Dose 50
  • Male
  • Mice
  • Motor Activity (drug effects)
  • Nervous System (drug effects)
  • Phenobarbital (pharmacology)
  • Phenytoin (pharmacology)
  • Picrotoxin
  • Rats
  • Rats, Inbred Strains
  • Receptors, GABA-A (drug effects)
  • Seizures (chemically induced, prevention & control)
  • Strychnine
  • Valproic Acid (pharmacology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: