ESR studies of molecular interactions of copper(II) nirvanol and copper(II) diisopropylsalicylate with Ehrlich ascites tumor cells.

Abstract

ESR spectra have been obtained after addition of either a cupric phenylhydantoin or a cupric diisopropylsalicylate complex to Ehrlich ascites tumor cells. It is shown that some of the complex remains in the cupric state. Because the ESR parameters of these complexes in the presence of cells differ from the ESR parameters for these complexes in the absence of cells, in the presence of cells either adducts or new cupric complexes are formed. The fast motion of these complexes, as determined from room temperature ESR spectra, is characteristic of complexes with molecular weights less than 1500.

• Authors: A Pezeshk, W E Antholine, D H Petering
• Journal: Journal of inorganic biochemistry (J Inorg Biochem) Vol. 31 Issue 4 Pg. 283-91 (Dec 1987) ISSN: 0162-0134 [Print] United States
• PMID: 2830367 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Hydantoins
• Organometallic Compounds
• Salicylates
• bis(5-ethyl-5-phenylhydantoin)bispyridine Cu(II)
• copper bis(3,5-diisopropylsalicylate)

Topics

• Animals
• Carcinoma, Ehrlich Tumor (metabolism)
• Chemical Phenomena
• Chemistry
• Electron Spin Resonance Spectroscopy (methods)
• Hydantoins (chemical synthesis, metabolism)
• In Vitro Techniques
• Mice
• Organometallic Compounds (chemical synthesis, metabolism)
• Salicylates (metabolism)