The Evaluation of Fibrin-Related Markers for Diagnosing or Predicting Acute or Subclinical Venous Thromboembolism in Patients Undergoing Major Orthopedic Surgery.

Abstract

OBJECTIVE:

The cutoff values of fibrin-related markers (FRMs) diagnosing or predicting the occurrence of a venous thromboembolism (VTE) were evaluated.

MATERIALS AND METHODS:

Fibrin-related markers such as fibrin monomer complex (FMC), D-dimer, and fibrinogen and fibrin degradation products (FDPs) before surgery were measured in 326 patients undergoing orthopedic surgery to diagnose subclinical VTE or predict postoperative VTE.

RESULTS:

Although the FMC, D-dimer, and FDP levels were all useful for the diagnosis of acute VTE, the FDP level was not useful for diagnosing subclinical VTE or predicting postoperative VTE. The results of several D-dimer assays closely correlated with other D-dimer assays. There were various cutoff ranges for diagnosing or predicting VTE. Some D-dimer assays were useful for diagnosing low levels of D-dimer and others were useful for diagnosing moderate to high D-dimer levels. Increased D-dimer levels were useful for diagnosing acute (cutoff values: 2.0-5.9 μg/mL) or about 10% of subclinical VTE (cutoff values: 3.4-5.3 μg/mL), for predicting about 10% of postoperative VTE (cutoff values: 3.4-5.3 μg/mL), and for excluding VTE.

CONCLUSION:

Although increased D-dimer levels were useful for diagnosing subclinical VTE and predicting the risk of VTE, there were various cutoff values for the diagnosis or prediction of VTE.

• Authors: Masahiro Hasegawa, Hideo Wada, Shinichi Miyazaki, Toshio Yamaguchi, Hiroki Wakabayashi, Naoki Fujimoto, Takeshi Matsumoto, Kohshi Ohishi, Akane Sakaguchi, Norikazu Yamada, Masaaki Ito, Yoshiki Yamashita, Naoyuki Katayama, Kaname Nakatani, Akihiro Sudo
• Journal: Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis (Clin Appl Thromb Hemost) Vol. 24 Issue 1 Pg. 107-114 (Jan 2018) ISSN: 1938-2723 [Electronic] United States
• PMID: 28301902 (Publication Type: Journal Article)

Chemical References

• Biomarkers
• Fibrin Fibrinogen Degradation Products
• fibrin fragment D
• Fibrinogen

Topics

• Acute Disease
• Aged
• Biomarkers (blood)
• Female
• Fibrin Fibrinogen Degradation Products (metabolism)
• Fibrinogen (metabolism)
• Humans
• Male
• Middle Aged
• Orthopedic Procedures (adverse effects)
• Postoperative Complications (blood)
• Venous Thromboembolism (blood, etiology)