In recent years, researchers have focused on targeted gene therapy for
lung cancer, using nanoparticle carriers to overcome the limitations of conventional treatment methods. The main goal of targeted gene therapy is to develop more efficient therapeutic strategies by improving the bioavailability, stability, and target specificity of gene
therapeutics and to reduce off-target effects.
Polymer-based nanoparticles, an alternative to
lipid and inorganic nanoparticles, efficiently carry
nucleic acid therapeutics and are stable in vivo. Receptor-targeted delivery is a promising approach that can limit non-specific gene delivery and can be achieved by modifying the
polymer nanoparticle surface with specific receptor
ligands or
antibodies. This review highlights the recent developments in gene delivery using synthetic and natural
polymer-based
nucleic acid carriers for
lung cancer treatment. Various nanoparticle systems based on
polymers and
polymer combinations are discussed. Further, examples of targeting
ligands or moieties used in targeted,
polymer-based gene delivery to
lung cancer are reviewed.