A comparison of PCP-like compounds for NMDA antagonism in two in vivo models.

Abstract

The PCP-like compounds ketamine and dexoxadrol were evaluated in two behavioral test procedures known to be sensitive to competitive N-methyl-D-aspartate (NMDA) receptor antagonists. In the NMDA-induced convulsion test in mice, ketamine and dexoxadrol blocked convulsant activity only at doses that also induced nonspecific effects of PCP-like behaviors, thereby confounding the interpretation of results. These compounds also blocked NMDA-induced discriminative stimuli in rats; however, this effect was produced at doses lower than those which induced the nonspecific behavioral effects. These results provide evidence that in behavioral procedures, PCP-like compounds may block excitatory amino acid receptor stimulation by NMDA. The NMDA discrimination identifies these interactions without the influence of motor deficit or other behavioral motor effects.

• Authors: D A Bennett, P S Bernard, C L Amrick
• Journal: Life sciences (Life Sci) Vol. 42 Issue 4 Pg. 447-54 ( 1988) ISSN: 0024-3205 [Print] Netherlands
• PMID: 2828792 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Dioxolanes
• Dioxoles
• Piperidines
• Receptors, N-Methyl-D-Aspartate
• Receptors, Neurotransmitter
• Aspartic Acid
• dioxadrol
• N-Methylaspartate
• Ketamine
• dexoxadrol

Topics

• Animals
• Aspartic Acid (analogs & derivatives, antagonists & inhibitors, pharmacology)
• Behavior, Animal (drug effects)
• Dioxolanes (pharmacology)
• Dioxoles (pharmacology)
• Ketamine (pharmacology)
• Male
• Mice
• Motor Activity (drug effects)
• N-Methylaspartate
• Piperidines (pharmacology)
• Rats
• Rats, Inbred Strains
• Receptors, N-Methyl-D-Aspartate
• Receptors, Neurotransmitter (drug effects, physiology)
• Seizures (chemically induced)