"Sporadic" prealbumin-related amyloid polyneuropathy: report of two cases.

Abstract

Two "sporadic" cases of amyloid polyneuropathy are reported. There was no family history or plasma cell dyscrasia. Both showed sensorimotor and autonomic polyneuropathy with onset in the seventh decade. Amyloid deposits in both cases reacted with anti-human prealbumin sera but not with antisera to human AA and anti-human immunoglobulin light-chain amyloids, including A kappa and A lambda. One patient had the abnormal serum prealbumin and abnormal DNA sequence found in type I familial amyloid polyneuropathy (FAP)(Japanese type). Investigations in "sporadic" amyloid polyneuropathy should include immunohistochemistry, using antisera to the different amyloid proteins, and the radioimmunoassay and recombinant DNA techniques for diagnosis of FAP.

• Authors: M Yamada, H Tsukagoshi, J Satoh, S Ishiai, M Nakazato, H Furuya, H Sasaki, Y Sakaki, T Yokota
• Journal: Journal of neurology (J Neurol) Vol. 235 Issue 2 Pg. 69-73 (Dec 1987) ISSN: 0340-5354 [Print] Germany
• PMID: 2828557 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Prealbumin
• Serum Amyloid A Protein

Topics

• Aged
• Amyloidosis (metabolism, pathology, physiopathology)
• Histocytochemistry
• Humans
• Male
• Myocardium (metabolism, pathology)
• Peripheral Nervous System Diseases (metabolism, pathology, physiopathology)
• Prealbumin (metabolism)
• Serum Amyloid A Protein (metabolism)
• Skin (metabolism, pathology)