The action of recombinant bovine interferons on influenza virus replication correlates with the induction of two Mx-related proteins in bovine cells.

Abstract

Recombinant bovine interferon-alpha and -gamma differ in their action against influenza virus on bovine cells. Bovine IFN-alpha severely impairs early protein synthesis and replication of influenza virus in bovine cells in contrast to bovine IFN-gamma which fails to induce an antiviral state against influenza virus. Otherwise the IFN system seems to function normally in bovine cells since both bovine IFN-alpha and -gamma induce an antiviral state against vesicular stomatitis virus. The establishment of the specific antiviral state against influenza virus correlates with the induction by bovine IFN-alpha, but not -gamma, of two cytoplasmic proteins related to the IFN-induced mouse protein Mx involved in the mechanism of resistance of mice to influenza virus infection. This study suggests that bovines possess a system for resistance to influenza virus similar to the mouse Mx system.

• Authors: M A Horisberger
• Journal: Virology (Virology) Vol. 162 Issue 1 Pg. 181-6 (Jan 1988) ISSN: 0042-6822 [Print] United States
• PMID: 2827376 (Publication Type: Journal Article)

Chemical References

• Interferon Type I
• Mx1 protein, mouse
• Myxovirus Resistance Proteins
• Proteins
• Recombinant Proteins
• Viral Proteins
• Interferon-gamma
• GTP-Binding Proteins

Topics

• Animals
• Cattle
• GTP-Binding Proteins
• Influenza A virus (growth & development)
• Interferon Type I (pharmacology)
• Interferon-gamma (pharmacology)
• Isoelectric Point
• Molecular Weight
• Myxovirus Resistance Proteins
• Proteins (physiology)
• Recombinant Proteins (pharmacology)
• Vesicular stomatitis Indiana virus (growth & development)
• Viral Interference
• Viral Proteins (biosynthesis)
• Virus Replication (drug effects)