Nephritogenic glycoprotein. XII. Focal glomerulonephritis with myeloid bodies produced in rats by synthetic analogues of the glycopeptide, nephritogenoside.

Abstract

Glomerular lesions were successfully induced in rats by a single footpad injection of synthetic analogues of nephritogenoside [alpha-Glc-(1----6)-alpha-Glc-(1-NHCO-Asn, and -Gln)]. Characteristic morphological changes of these glomerular lesions are (1) focal glomerulonephritis (FGN) and (2) the appearance of myeloid bodies in the epithelial cells of the podocytes. FGN produced by a single injection of the synthetic analogues of nephritogenoside may provide an experimental animal model of this potentially diffuse disease, since morphological changes in the early stage of sclerosing glomerulonephritis (end-stage kidney) induced by a single footpad injection of natural nephritogenoside are often identical to those of FGN.

• Authors: S Shibata, M Okada, Y Natori, N Shindo, M Oshima
• Journal: Nephron (Nephron) Vol. 47 Issue 2 Pg. 101-8 ( 1987) ISSN: 1660-8151 [Print] Switzerland
• PMID: 2827042 (Publication Type: Journal Article)

Chemical References

• Glycopeptides
• Trisaccharides
• Glutamine
• Asparagine
• glucosyl-glucosyl-glucosyl-asparagine
• glycotriosyl glutamine

Topics

• Animals
• Asparagine (analogs & derivatives)
• Cells, Cultured
• Disease Models, Animal
• Fluorescent Antibody Technique
• Glomerulonephritis (chemically induced, pathology)
• Glutamine (analogs & derivatives)
• Glycopeptides
• Humans
• Inclusion Bodies (ultrastructure)
• Kidney Glomerulus (ultrastructure)
• Kidney Tubules, Proximal (ultrastructure)
• Male
• Rats
• Rats, Inbred Strains
• Trisaccharides