Abstract | PURPOSE: METHODS:
Cubilin protein expression was analyzsed in tumor tissue from a cohort of patients with metastatic renal cell cancer (n = 139) using immunohistochemistry. One hundred and thirty six of the patients were treated with sunitinib or sorafenib in the first- or second-line setting. Thirty of these were censored because of toxicity leading to the termination of treatment and the remaining (n = 106) were selected for the current study. RESULTS: Fifty-three (50%) of the tumors expressed cubilin in the membrane. The median progression-free survival was 8 months in patients with cubilin expressing tumors and 4 months in the cubilin negative group. In addition, the overall survival was better for patients with cubilin positive tumors. We also found that the fraction of cubilin negative patients was significantly higher in the non-responding group (PFS ≤3 months) compared to responding patients (PFS >3 months). CONCLUSIONS:
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Authors | Marjut Niinivirta, Gunilla Enblad, Per-Henrik Edqvist, Fredrik Pontén, Anca Dragomir, Gustav J Ullenhag |
Journal | Journal of cancer research and clinical oncology
(J Cancer Res Clin Oncol)
Vol. 143
Issue 6
Pg. 961-970
(Jun 2017)
ISSN: 1432-1335 [Electronic] Germany |
PMID | 28260162
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers, Pharmacological
- Biomarkers, Tumor
- Indoles
- Phenylurea Compounds
- Pyrroles
- Receptors, Cell Surface
- intrinsic factor-cobalamin receptor
- Niacinamide
- Sorafenib
- Sunitinib
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Biomarkers, Pharmacological
(metabolism)
- Biomarkers, Tumor
(metabolism)
- Carcinoma, Renal Cell
(diagnosis, drug therapy, pathology)
- Disease-Free Survival
- Drug Monitoring
- Female
- Humans
- Indoles
(therapeutic use)
- Kidney Neoplasms
(diagnosis, drug therapy, pathology)
- Male
- Middle Aged
- Niacinamide
(analogs & derivatives, therapeutic use)
- Phenylurea Compounds
(therapeutic use)
- Prognosis
- Pyrroles
(therapeutic use)
- Receptors, Cell Surface
(metabolism)
- Sorafenib
- Sunitinib
- Treatment Outcome
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