Lack of therapeutic activity of the lipoidal amine CP-46,665 in rodent tumors and human non-seminomatous germ cell tumors growing in nude mice.

Abstract

The alkyl-linked lipoidal amine 4-aminomethyl-1-[2,3-(di-n-decyloxy)-n-propyl]-4-phenylpiperidine (CP-46,665) was tested for therapeutic activity in 2 rodent tumor models and 2 human non-seminomatous germ cell tumors growing in nude mice. CP-46,665 failed to show therapeutic efficacy in 3-Lewis lung carcinoma (3-LL) growing in syngeneic C57Bl6-mice, in methylnitrosourea (MNU)-induced rat mammary carcinomas and in 2 human non-seminomatous germ cell tumor cell lines (H 12.1, H 12.7) growing in nu/nu NMRI-mice when given in a dose range including non-toxic doses and doses higher than the lethal dose for 10% of the treated animals (LD10).

• Authors: W E Berdel, M R Berger, H Falk, A Harstrick, S Danhauser, H D Schick, H J Schmoll, D Schmähl, W R Vogler, J Rastetter
• Journal: Cancer letters (Cancer Lett) Vol. 38 Issue 1-2 Pg. 191-7 (Dec 1987) ISSN: 0304-3835 [Print] Ireland
• PMID: 2825966 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antineoplastic Agents
• Piperidines
• CP 46665

Topics

• Animals
• Antineoplastic Agents (therapeutic use)
• Female
• Humans
• Mammary Neoplasms, Experimental (drug therapy)
• Mice
• Mice, Inbred C57BL
• Mice, Nude
• Neoplasm Transplantation
• Neoplasms, Experimental (drug therapy)
• Neoplasms, Germ Cell and Embryonal (drug therapy)
• Piperidines (therapeutic use)
• Rats
• Rats, Inbred Strains
• Transplantation, Heterologous