Assessment of biventricular systolic strain derived from the two-dimensional and three-dimensional speckle tracking echocardiography in lymphoma patients after anthracycline therapy.

Abstract

The aim of this study was to investigate the usefulness of three-dimensional (3D) speckle tracking echocardiography (STE) for assessment of both left and right ventricular systolic function in patients with lymphoma after anthracycline chemotherapy, compared with two-dimensional (2D) STE. Totally eighty-nine patients undergoing anthracycline containing chemotherapy were studied. Echocardiographic assessment included 2D and 3D left ventricular (LV) global longitudinal strain (GLS), global circumferential strain (GCS) and right ventricular (RV) GLS. All the parameters were analyzed at baseline, after the completion of four cycles and at the end of the regimen respectively. The area under the receiver operating characteristic curve was calculated to determine the capability of various echocardiographic parameters to discriminate between before and after chemotherapy. Compared with those at baseline, the 3D GLS and GCS of LV and GLS of RV decreased significantly after four cycles of the therapy (all p < 0.01). At the end of the treatment, 2D GLS and GCS of LV deteriorated markedly (both p < 0.05). The area under the curve for GLS, GCS of LV and GLS of RV derived by 3D were 0.81, 0.66 and 0.78, respectively. The cutoff value with -20.4% of LV GLS by 3D had sensitivity of 81% and specificity of 66% for differentiating patients after therapy from baselines. The cutoff value with -21.9% of RV GLS by 3D had sensitivity of 71% and specificity of 74% fordifferentiating patients after therapy from baselines. The data from this study demonstrated that both 2D and 3D STE can be conducted to evaluate the slight myocardial damage for lymphoma patients after anthracycline chemotherapy. 3D STE could examine subclinical biventricular dysfunction in earlier point than 2D STE.

• Authors: Fei-Yan Song, Jing Shi, Ye Guo, Chu-Jie Zhang, Yu-Chen Xu, Qun-Ling Zhang, Xian-Hong Shu, Lei-Lei Cheng
• Journal: The international journal of cardiovascular imaging (Int J Cardiovasc Imaging) Vol. 33 Issue 6 Pg. 857-868 (Jun 2017) ISSN: 1875-8312 [Electronic] United States
• PMID: 28255826 (Publication Type: Journal Article)

Chemical References

• Anthracyclines
• Antibiotics, Antineoplastic
• Biomarkers

Topics

• Adult
• Aged
• Anthracyclines (adverse effects)
• Antibiotics, Antineoplastic (adverse effects)
• Area Under Curve
• Biomarkers (blood)
• Biomechanical Phenomena
• Cardiotoxicity
• Early Diagnosis
• Echocardiography, Doppler, Pulsed
• Echocardiography, Three-Dimensional
• Female
• Heart Diseases (blood, chemically induced, diagnostic imaging, physiopathology)
• Humans
• Image Interpretation, Computer-Assisted
• Lymphoma, Large B-Cell, Diffuse (drug therapy)
• Male
• Middle Aged
• Observer Variation
• Predictive Value of Tests
• Prospective Studies
• ROC Curve
• Reproducibility of Results
• Risk Factors
• Stress, Mechanical
• Systole
• Time Factors
• Ventricular Function, Left (drug effects)
• Ventricular Function, Right (drug effects)
• Young Adult