Effect of the addition of nano-sized sodium hexametaphosphate to fluoride toothpastes on tooth demineralization: an in vitro study.

Abstract

OBJECTIVE:

This study evaluated the effect of toothpastes containing 1100 ppm F associated with nano-sized sodium hexametaphosphate (HMPnano) on enamel demineralization in vitro using a pH-cycling model.

DESIGN:

Bovine enamel blocks (4 mm × 4 mm, n = 72) selected by initial surface hardness (SHi) were randomly allocated into six groups (n = 12), according to the test toothpastes: without fluoride or HMPnano (Placebo), 550 ppm F (550F), 1100 ppm F (1100F), 1100F plus HMPnano at concentrations of 0.25% (1100F/0.25%HMPnano), 0.5% (1100F/0.5%HMPnano), and 1.0% (1100F/1.0%HMPnano). Blocks were treated 2×/day with slurries of toothpastes and submitted to five pH cycles (demineralizing/remineralizing solutions) at 37 °C. Next, final surface hardness (SHf), integrated loss subsurface hardness (ΔKHN), integrated mineral loss (gHAp × cm-3), and enamel fluoride (F) concentrations were determined. Data were analyzed by ANOVA and Student-Newman-Keuls test (p < 0.001).

RESULTS:

Toothpaste with 1100F/0.5%HMPnano led to the lowest mineral loss and the highest mineral concentration among all groups, which were 26% (SHf) and 21% (ΔKHN) lower and ~58% higher (gHAp × cm-3) when compared to 1100F (p < 0.001). Similar values of enamel F were observed for all fluoridated toothpastes (p > 0.001).

CONCLUSION:

The addition of 0.5%HMPnano to a 1100 F toothpaste significantly enhances its effects against enamel demineralization when compared to its counterpart without HMPnano in vitro.

CLINICAL SIGNIFICANCE:

Toothpaste containing 1100 ppm F associated with HMPnano has a higher potential to reduce the demineralization compared to 1100 ppm F. This toothpaste could be a viable alternative to patients at high risk of caries.

• Authors: Giovanna Dalpasquale, Alberto Carlos Botazzo Delbem, Juliano Pelim Pessan, Gabriel Pereira Nunes, Luiz Fernando Gorup, Francisco Nunes Souza Neto, Emerson Rodrigues de Camargo, Marcelle Danelon
• Journal: Clinical oral investigations (Clin Oral Investig) Vol. 21 Issue 5 Pg. 1821-1827 (Jun 2017) ISSN: 1436-3771 [Electronic] Germany
• PMID: 28243757 (Publication Type: Journal Article)

Chemical References

• Phosphates
• Toothpastes
• fluorophosphate
• sodium polymetaphosphate
• Fluorides

Topics

• Animals
• Cattle
• Dental Enamel (drug effects)
• Fluorides (pharmacology)
• Hardness
• Hydrogen-Ion Concentration
• In Vitro Techniques
• Nanostructures
• Phosphates (pharmacology)
• Random Allocation
• Surface Properties
• Tooth Demineralization (chemically induced)
• Toothpastes (pharmacology)