Viral antibody titers. Comparison in patients with multiple sclerosis and rheumatoid arthritis.

Abstract

Higher titers of antibodies to measles virus envelope antigens, hemolysin and hemagglutinin, Epstein-Barr virus (EBV) capsid antigen and nuclear antigen, and rubella virus hemagglutinin were demonstrated in serum samples of patients with multiple sclerosis and rheumatoid arthritis than in age- and sex-matched control subjects. A significant correlation was observed between antibodies to measles and rubella viruses both in patients with multiple sclerosis and rheumatoid arthritis, but such a correlation was not observed between antibodies to EBV and measles or rubella viruses. Whether elevated levels of antibodies to EBV are due to reactivation of the virus, or elevated levels of antibodies to all the enveloped viruses result from cross-reactions between viruses and host tissue, or perhaps reflect defects in immunoregulation, needs further investigation.

• Authors: P V Shirodaria, M Haire, E Fleming, J D Merrett, S A Hawkins, S D Roberts
• Journal: Archives of neurology (Arch Neurol) Vol. 44 Issue 12 Pg. 1237-41 (Dec 1987) ISSN: 0003-9942 [Print] United States
• PMID: 2823754 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Viral
• Antigens, Viral
• Epstein-Barr Virus Nuclear Antigens
• Hemagglutinins, Viral
• Hemolysin Proteins

Topics

• Adult
• Aged
• Antibodies, Viral (analysis)
• Antigens, Viral (immunology)
• Arthritis, Rheumatoid (immunology)
• Cross Reactions
• Epstein-Barr Virus Nuclear Antigens
• Female
• Hemagglutinins, Viral (immunology)
• Hemolysin Proteins (immunology)
• Herpesvirus 4, Human (immunology)
• Humans
• Male
• Measles virus (immunology)
• Middle Aged
• Multiple Sclerosis (immunology)
• Rubella virus (immunology)