HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Agonist/antagonist activity of ergocristine at alpha-adrenoceptors in the rat.

Abstract
(1) The action of ergocristine at alpha-adrenoceptors was studied in vivo in the pithed rat, and in vitro on the rat isolated vas deferens. (2) In the pithed rat, the pressor response to ergocristine was reduced competitively by yohimbine, but not by prazosin. (3) Ergocristine decreased the tachycardia elicited by electrical stimulation of the cardioaccelerator sympathetic nerves, this effect being antagonized by yohimbine. (4) At postsynaptic alpha 1-adrenoceptors, on the vas deferens of the rat, ergocristine antagonized the contraction induced by phenylephrine in a competitive manner (pA2 = 7.85). (5) These results show that vasoconstriction due to ergocristine is mediated by alpha 2-adrenoceptors and that, in the rat, ergocristine acts as an alpha 2-adrenoceptors agonist, and an alpha 1-adrenoceptors antagonist.
AuthorsJ Roquebert, P Demichel
JournalFundamental & clinical pharmacology (Fundam Clin Pharmacol) Vol. 1 Issue 1 Pg. 23-33 ( 1987) ISSN: 0767-3981 [Print] England
PMID2822556 (Publication Type: Journal Article)
Chemical References
  • Ergolines
  • Receptors, Adrenergic, alpha
  • ergocristine
  • Isoproterenol
Topics
  • Animals
  • Blood Pressure (drug effects)
  • Decerebrate State
  • Drug Interactions
  • Ergolines (pharmacology)
  • Heart Rate (drug effects)
  • In Vitro Techniques
  • Isoproterenol (pharmacology)
  • Male
  • Rats
  • Rats, Inbred Strains
  • Receptors, Adrenergic, alpha (drug effects, metabolism)
  • Vas Deferens (drug effects)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: