Abstract |
(1) The action of ergocristine at alpha- adrenoceptors was studied in vivo in the pithed rat, and in vitro on the rat isolated vas deferens. (2) In the pithed rat, the pressor response to ergocristine was reduced competitively by yohimbine, but not by prazosin. (3) Ergocristine decreased the tachycardia elicited by electrical stimulation of the cardioaccelerator sympathetic nerves, this effect being antagonized by yohimbine. (4) At postsynaptic alpha 1-adrenoceptors, on the vas deferens of the rat, ergocristine antagonized the contraction induced by phenylephrine in a competitive manner (pA2 = 7.85). (5) These results show that vasoconstriction due to ergocristine is mediated by alpha 2-adrenoceptors and that, in the rat, ergocristine acts as an alpha 2-adrenoceptors agonist, and an alpha 1-adrenoceptors antagonist.
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Authors | J Roquebert, P Demichel |
Journal | Fundamental & clinical pharmacology
(Fundam Clin Pharmacol)
Vol. 1
Issue 1
Pg. 23-33
( 1987)
ISSN: 0767-3981 [Print] England |
PMID | 2822556
(Publication Type: Journal Article)
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Chemical References |
- Ergolines
- Receptors, Adrenergic, alpha
- ergocristine
- Isoproterenol
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Topics |
- Animals
- Blood Pressure
(drug effects)
- Decerebrate State
- Drug Interactions
- Ergolines
(pharmacology)
- Heart Rate
(drug effects)
- In Vitro Techniques
- Isoproterenol
(pharmacology)
- Male
- Rats
- Rats, Inbred Strains
- Receptors, Adrenergic, alpha
(drug effects, metabolism)
- Vas Deferens
(drug effects)
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