Abstract | OBJECTIVE: METHODS: A prospective study was conducted in patients with transfusion-dependent β- thalassemia major in a tertiary care center over 2 years. Patients on either DFP or DFX who were not improving on monotherapy over a long period and persistently maintaining serum ferritin >2500 µg/L were enrolled. Efficacy was assessed by serum ferritin levels assessed at 12 months and 2 years. Complete blood counts and liver and kidney function tests were monitored to assess the safety of the combination of drugs. RESULTS: In total, 33 patients with a mean age of 12.67 years (7.5 to 17.5 y) and a mean ferritin of 4835.2394±1443.85 µg/L formed the study cohort.In total, 28 patients completed the 1-year study period; and 12 patients completed 2 years. Mean serum ferritin reduction at 1 and 2 years was 34.99%±18.13% (range, -34.36% to 56.17%) and 44.67%±13.78% (range, 22.17% to 62.74%), respectively. The combination therapy was well tolerated. CONCLUSIONS: Combined oral chelation with DFP and DFX has better efficacy than either drug used alone. The combination of drugs was well tolerated and no new adverse effects were observed.
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Authors | Nupur Parakh, Jagdish Chandra, Sunita Sharma, Bhavna Dhingra, Rajesh Jain, DeoNath Mahto |
Journal | Journal of pediatric hematology/oncology
(J Pediatr Hematol Oncol)
Vol. 39
Issue 3
Pg. 209-213
(04 2017)
ISSN: 1536-3678 [Electronic] United States |
PMID | 28221264
(Publication Type: Journal Article, Observational Study)
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Chemical References |
- Benzoates
- Iron Chelating Agents
- Pyridones
- Triazoles
- Deferiprone
- Ferritins
- Deferoxamine
- Deferasirox
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Topics |
- Adolescent
- Benzoates
(therapeutic use)
- Blood Transfusion
- Child
- Deferasirox
- Deferiprone
- Deferoxamine
(therapeutic use)
- Drug Therapy, Combination
- Female
- Ferritins
(blood)
- Humans
- India
- Iron Chelating Agents
- Kidney Function Tests
- Liver Function Tests
- Male
- Prospective Studies
- Pyridones
(therapeutic use)
- Tertiary Care Centers
- Triazoles
(therapeutic use)
- beta-Thalassemia
(drug therapy)
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