Biochemistry and neurotoxicology of guanidino compounds. History and recent advances.

Guanidino compounds are known to have important biological roles, such as the participation of arginine in ureagenesis, and of creatine in muscular contraction. On the other hand, the high toxicity of guanidino compounds, such as methylguanidine and guanidine, has been under study for quite a long time in the biochemical as well as clinical fields. In this review, the author summarizes the experimental results of neurophysiological and neurochemical studies on guanidino compound-induced seizures, conducted by his colleagues since 1966, and introduces several topics arising from their recent investigations on guanidino compounds and seizure mechanism, i.e., (1) alpha-guanidino-glutaric acid in the cobalt epileptic focus and its convulsive activity; (2) guanidino-ethanesulfonic acid and epilepsy; (3) delta-guanidinovaleric acid, and endogenous and specific GABA receptor antagonist; and (4) guanidino compounds as radical generators.
AuthorsA Mori
JournalThe Pavlovian journal of biological science (Pavlov J Biol Sci) 1987 Jul-Sep Vol. 22 Issue 3 Pg. 85-94 ISSN: 0093-2213 [Print] UNITED STATES
PMID2821470 (Publication Type: Historical Article, Journal Article, Review)
Chemical References
  • Convulsants
  • Glutarates
  • Guanidines
  • Receptors, GABA-A
  • Valerates
  • delta-guanidinovaleric acid
  • alpha-guanidinoglutaric acid
  • Animals
  • Convulsants
  • Epilepsy (chemically induced)
  • Glutarates (toxicity)
  • Guanidines (history, toxicity)
  • History, 19th Century
  • History, 20th Century
  • Nervous System (drug effects)
  • Receptors, GABA-A (drug effects)
  • Valerates (toxicity)

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