| Abstract | The results of 63 patients with advanced malignant tumors treated by combined chemotherapy including high-dose cisplatin (HD-DDP) (single dose 50-100 mg/m2) are reported. The remission rates and duration of the remission for various malignant tumors were: 40% (10 PR out of 25 patients) and 3-8 months for non-small cell lung cancer (NSCLC) treated by PMFV (DDP, MMC, 5FU and VCR) regimen; 87% (4 CR and 9 PR out of 15) and 3-14 months for breast cancer treated by PCMF (DDP, CTX, MTX and 5FU) regimen; 100% (1 CR and 3 PR out of 4) and 3-10 months for testicular cancer treated by PPV (DDP, Pingyangmycin and VCR) regimen; 57% (1CR and 3 PR out of 7) and 5-12 months for malignant melanoma treated by PBDV (DDP, BCNU, DTIC and VCR) regimen; 33% (2 PR out of 6) and 5 months for esophageal cancer treated by PPV regimen. In 6 patients with other malignant tumors, the remission rate was 50% (3 PR). The results show that the combined regimens including HD-DDP in the treatment of breast cancer and NSCLC (remission rate 87% and 40%, respectively) are better than that including low-dose DDP (17% and 7%) (P less than 0.001, P less than 0.01) and that including adriamycin (30% and 13%) (P less than 0.001, P less than 0.05). In the treatment, obvious gastrointestinal reaction, leukopenia, thrombocytopenia and mild functional damage of the liver and kidney were observed. |
| Authors | J C Zhou, F Y Feng, Y Sun, Q L Wang, W Y Zeng, Y Y Liu
(Affiliation: Cancer Hospital, Chinese Academy of Medical Sciences, Beijing.)
|
| Journal | Zhonghua zhong liu za zhi [Chinese journal of oncology]
(Zhonghua Zhong Liu Za Zhi)
Vol. 9
Issue 2
Pg. 136-9
(Mar 1987)
ISSN: 0253-3766 CHINA |
| PMID | 2820683
(Publication Type: English Abstract, Journal Article)
|
| Chemical References |
- Mitomycins
- PCMF protocol
- PMFV protocol
- Cisplatin
- Mitomycin
- Cyclophosphamide
- Fluorouracil
- Vincristine
- Methotrexate
|
| Topics |
- Adult
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Breast Neoplasms
(drug therapy)
- Carcinoma, Non-Small-Cell Lung
(drug therapy)
- Cisplatin
(administration & dosage)
- Cyclophosphamide
(administration & dosage)
- Female
- Fluorouracil
(administration & dosage)
- Humans
- Lung Neoplasms
(drug therapy)
- Male
- Methotrexate
(administration & dosage)
- Middle Aged
- Mitomycin
- Mitomycins
(administration & dosage)
- Vincristine
(administration & dosage)
|
