Abstract |
The active principle of Jawaharene (JF1), a mixture of fatty acids, was studied for antitumor properties against Ehrlich Ascites Carcinoma (EAC) and Sarcoma-180 (S-180). Using a Warburg respirometer, respiratory O2-uptake by EAC and S-180 cells was completely inhibited by JF1 at the dose of 100 micrograms ml-1. The in vitro cytotoxicity assay revealed that 100% of JF1-treated tumor cells were killed within 60 min incubation. In vivo, EAC and S-180 ascites tumor development was completely inhibited by JF1 at the dose of 5 mg mouse-1 day-1 X 8.
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Authors | A K Das |
Journal | Cancer letters
(Cancer Lett)
Vol. 48
Issue 2
Pg. 147-51
(Nov 30 1989)
ISSN: 0304-3835 [Print] Ireland |
PMID | 2819702
(Publication Type: Journal Article)
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Chemical References |
- Antibiotics, Antineoplastic
- Oleic Acids
- Organic Chemicals
- jawaharene
- Oleic Acid
|
Topics |
- Animals
- Antibiotics, Antineoplastic
(analysis, pharmacology)
- Ascites
- Cell Survival
(drug effects)
- Male
- Mice
- Neoplasms, Experimental
(drug therapy)
- Oleic Acid
- Oleic Acids
(pharmacology)
- Organic Chemicals
- Oxygen Consumption
(drug effects)
- Tumor Cells, Cultured
(drug effects)
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