HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Antitumor property of the active principle of jawaharene.

Abstract
The active principle of Jawaharene (JF1), a mixture of fatty acids, was studied for antitumor properties against Ehrlich Ascites Carcinoma (EAC) and Sarcoma-180 (S-180). Using a Warburg respirometer, respiratory O2-uptake by EAC and S-180 cells was completely inhibited by JF1 at the dose of 100 micrograms ml-1. The in vitro cytotoxicity assay revealed that 100% of JF1-treated tumor cells were killed within 60 min incubation. In vivo, EAC and S-180 ascites tumor development was completely inhibited by JF1 at the dose of 5 mg mouse-1 day-1 X 8.
AuthorsA K Das
JournalCancer letters (Cancer Lett) Vol. 48 Issue 2 Pg. 147-51 (Nov 30 1989) ISSN: 0304-3835 [Print] Ireland
PMID2819702 (Publication Type: Journal Article)
Chemical References
  • Antibiotics, Antineoplastic
  • Oleic Acids
  • Organic Chemicals
  • jawaharene
  • Oleic Acid
Topics
  • Animals
  • Antibiotics, Antineoplastic (analysis, pharmacology)
  • Ascites
  • Cell Survival (drug effects)
  • Male
  • Mice
  • Neoplasms, Experimental (drug therapy)
  • Oleic Acid
  • Oleic Acids (pharmacology)
  • Organic Chemicals
  • Oxygen Consumption (drug effects)
  • Tumor Cells, Cultured (drug effects)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: