Abstract |
In organ bath experiments, amphiphilic lipids lysophosphatidylcholine (LPC) and palmitylcarnitine (PLC) produced a small increase in tension of nonprecontracted strips of porcine coronary artery with a subsequent decrease to initial level after high concentrations of the agents, both in intact and endothelium-denuded preparations. Both amphiphiles produced dose-dependent but incomplete relaxation of intact coronary strips precontracted with high potassium. The effect of PLC was more pronounced. LPC, 3.10(-6) mol.l-1, did not influence Ca++-dose-response relationships, while PLC in concentration of 10(-5) mol.l-1 abolished the decline in the second Ca++-dose-response curve. Neither PLC nor LPC in concentrations of 3.10(-6) mol.l-1 influenced endothelium-dependent relaxation produced by bradykinin precontracted with high potassium porcine coronary artery. Both amphiphiles did not change tension of nonprecontracted and precontracted with phenylephrine, 10(-6) mol.l-1, rabbit femoral artery ring segments or Ca++-dose-response relationships with and without endothelium.
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Authors | Vedernikov YuP, T Gräser, N Tiedt, A M Vikhert |
Journal | Basic research in cardiology
(Basic Res Cardiol)
1989 Jul-Aug
Vol. 84
Issue 4
Pg. 371-7
ISSN: 0300-8428 [Print] Germany |
PMID | 2818436
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Lysophosphatidylcholines
- Palmitoylcarnitine
- Phenylephrine
- Potassium
- Carnitine
- Bradykinin
- Calcium
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Topics |
- Animals
- Bradykinin
(pharmacology)
- Calcium
(pharmacology)
- Carnitine
(analogs & derivatives)
- Coronary Vessels
(drug effects)
- Dose-Response Relationship, Drug
- Endothelium, Vascular
(metabolism)
- Femoral Artery
(drug effects)
- In Vitro Techniques
- Lysophosphatidylcholines
(pharmacology)
- Palmitoylcarnitine
(pharmacology)
- Phenylephrine
(pharmacology)
- Potassium
(pharmacology)
- Rabbits
- Swine
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