Long-term follow-up of Dupuytren disease after injection of triamcinolone acetonide in Chinese patients in Taiwan.

Abstract

Injection of triamcinolone acetonide is a non-operative treatment for early-stage Dupuytren disease in Caucasians, but its effectiveness in non-Caucasians is unclear. We report averaged 5-year follow-up results of 37 patients (49 affected hands) with early-stage Dupuytren disease for patients in Taiwan (non-Caucasian) who received a single dose of 5 mg triamcinolone acetonide injection into nodules monthly for 3 months. Using ultrasound, we recorded no progression of sizes of the modules following injection after 6 months. After an average 5-year follow-up, two patients with three hands (6%) experienced reactivation of the treated nodules. None required surgical intervention. Ultrasound examination showed that sizes of the treated Dupuytren nodules decreased significantly by 40% 6 months after injection and 56% at the final follow-up. We conclude that in these Chinese patients in Taiwan with early Dupuytren nodules, triamcinolone acetonide injection was effective in reducing the size of the Dupuytren nodules and maintaining long-term durable control of the nodular growth.

LEVEL OF EVIDENCE:

III.

• Authors: C-Y Yin, H-H M Yu, J-P Wang, Y-C Huang, T-F Huang, M-C Chang
• Journal: The Journal of hand surgery, European volume (J Hand Surg Eur Vol) Vol. 42 Issue 7 Pg. 678-682 (Sep 2017) ISSN: 2043-6289 [Electronic] England
• PMID: 28183220 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Glucocorticoids
• Triamcinolone Acetonide

Topics

• Aged
• Aged, 80 and over
• Asian People
• Disease Progression
• Dupuytren Contracture (diagnostic imaging, drug therapy, ethnology)
• Female
• Follow-Up Studies
• Glucocorticoids (administration & dosage)
• Humans
• Injections, Intralesional
• Male
• Middle Aged
• Taiwan
• Triamcinolone Acetonide (administration & dosage)
• Ultrasonography