Abstract | AIMS: METHODS AND RESULTS: We examined the association between baseline and follow-up serum ArylE activity and HF outcomes ( death, cardiac transplantation, or ventricular assist device implantation) in 299 patients with HF enrolled in a prospective cohort study from January 2008 to July 2009, with 145 patients having available follow-up levels at 1 year. A significant drop in ArylE activity on follow-up was defined as a drop of ≥25% vs. baseline levels. Mean baseline and follow-up ArylE activity levels were 110.6 ± 29.9 µmol/min/mL and 106.2 ± 29.9 µmol/min/mL, respectively. After a mean follow-up of 2.8 ± 1.1 years, low baseline ArylE activity was associated with increased risk of adverse HF events [hazard ratio (HR; lowest vs highest tertile) 2.6, 95% confidence interval (CI) 1.3-5.5, P = 0.01] and HF-related hospitalization [incidence rate ratio (lowest vs. highest tertile) 2.1, 95% CI 1.2-4.1, P = 0.016], which remained significant after adjustment for age, male gender, systolic blood pressure, diabetes, creatinine clearance, CAD, and HDL-cholesterol levels. Patients who had a significant drop in ArylE activity on follow-up (n = 18) had a significantly increased risk of HF events (HR 4.9, 95% CI 1.6-14.6, P = 0.005), even after adjustment for baseline levels of ArylE activity. CONCLUSIONS: Reduced baseline ArylE activity and decreased levels on follow-up are associated with adverse outcomes in stable outpatients with HF.
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Authors | Muhammad Hammadah, Andreas P Kalogeropoulos, Vasiliki V Georgiopoulou, Malory Weber, Yuping Wu, Stanley L Hazen, Javed Butler, W H Wilson Tang |
Journal | European journal of heart failure
(Eur J Heart Fail)
Vol. 19
Issue 6
Pg. 748-755
(06 2017)
ISSN: 1879-0844 [Electronic] England |
PMID | 28176482
(Publication Type: Journal Article, Multicenter Study, Research Support, N.I.H., Extramural)
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Copyright | © 2017 The Authors. European Journal of Heart Failure © 2017 European Society of Cardiology. |
Chemical References |
- Lipoproteins, HDL
- Carboxylic Ester Hydrolases
- arylesterase
- Aryldialkylphosphatase
|
Topics |
- Aryldialkylphosphatase
(blood)
- Carboxylic Ester Hydrolases
(blood)
- Disease Progression
- Female
- Follow-Up Studies
- Georgia
(epidemiology)
- Heart Failure
(blood, mortality, therapy)
- Humans
- Lipoproteins, HDL
(blood)
- Male
- Middle Aged
- Outpatients
- Prognosis
- Retrospective Studies
- Survival Rate
(trends)
- Time Factors
|