Skeletal effects of vitamin D deficiency among patients with primary hyperparathyroidism.

Abstract

Little is known about the association between vitamin D deficiency and the skeletal phenotypes in primary hyperparathyroidism (PHPT) patients. A low 25-hydroxyvitamin D level was associated with a low bone mineral density and deteriorated hip geometry in women with PHPT in an Asian population where vitamin D deficiency is prevalent.

INTRODUCTION:

Few studies have examined the effect of vitamin D deficiency on the bone health of primary hyperparathyroidism (PHPT) patients.

METHODS:

We investigated the skeletal effects of vitamin D deficiency in 79 PHPT patients by assessing bone mineral density (BMD), the trabecular bone score (TBS), and hip geometry, which were measured using dual-energy X-ray absorptiometry (27 men with median age 60 years [53;69]; 52 postmenopausal women with median age of 57 years [53;67]). Cross-sectional data were collected from subjects enrolled in an ongoing PHPT cohort study at Seoul National University Hospital from March 2008 to December 2015.

RESULTS:

We classified PHPT patients according to 25-hydroxyvitamin D (25(OH)D) levels (<20 vs. ≥20 ng/ml). After adjusting for age and body mass index, women with vitamin D deficiency had lower BMDs at the lumbar spine (LS) and femur neck (FN) than women who had sufficient levels of vitamin D (LS, 0.903 ± 0.138 vs. 0.998 ± 0.184 g/cm2; FN, 0.715 ± 0.084 vs. 0.791 ± 0.113 g/cm2; P < 0.05). However, the total hip BMD and the TBS were not significantly different between the two groups. In the hip geometry analysis, the cross-sectional area, cross-sectional moment of inertia, and section modulus were also significantly lower in women with vitamin D deficiency than in those without. No significant difference was found in the BMD, TBS, or hip geometry according to 25(OH)D levels in men.

CONCLUSION:

Vitamin D deficiency may be associated with a low BMD and deteriorated hip geometry in postmenopausal women with PHPT.

• Authors: J H Lee, J H Kim, A R Hong, S W Kim, C S Shin
• Journal: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA (Osteoporos Int) Vol. 28 Issue 5 Pg. 1667-1674 (05 2017) ISSN: 1433-2965 [Electronic] England
• PMID: 28175978 (Publication Type: Journal Article)

Chemical References

• Vitamin D
• 25-hydroxyvitamin D

Topics

• Absorptiometry, Photon (methods)
• Aged
• Anthropometry (methods)
• Bone Density (physiology)
• Cross-Sectional Studies
• Female
• Femur Neck (physiopathology)
• Hip Joint (pathology, physiopathology)
• Humans
• Hyperparathyroidism, Primary (blood, complications, physiopathology)
• Lumbar Vertebrae (physiopathology)
• Male
• Middle Aged
• Osteoporosis (blood, etiology, physiopathology)
• Osteoporosis, Postmenopausal (blood, etiology, pathology, physiopathology)
• Sex Factors
• Vitamin D (analogs & derivatives, blood)
• Vitamin D Deficiency (blood, complications, physiopathology)