[Protective action of kopsinine F against experimental liver injury in mice].

Abstract

Kopsinine F is an indole alkaloid. The present studies show that prior oral administration of kopsinine F 150 mg/kg significantly protected mice from liver injuries induced by intraperitoneal injection of CCl4, thioacetamide and acetaminophen. The alkaloid also inhibited CCl4 induced lipid peroxidation (MDA formation) of liver microsomes and 14CCl4 covalent binding to lipids of liver microsomes in vitro. In addition, kopsinine F significanty induced hepatic microsomal cytochrome P-450 in mice. The results indicate that kopsinine F has hpatoeprotective activity in mice.

• Authors: J Zhang, G T Liu
• Journal: Yao xue xue bao = Acta pharmaceutica Sinica (Yao Xue Xue Bao) Vol. 24 Issue 3 Pg. 165-9 ( 1989) ISSN: 0513-4870 [Print] China
• PMID: 2816370 (Publication Type: Journal Article)

Chemical References

• Alkaloids
• Thioacetamide
• kopsinine F
• Acetaminophen
• Cytochrome P-450 Enzyme System

Topics

• Acetaminophen
• Alkaloids (pharmacology, therapeutic use)
• Animals
• Carbon Tetrachloride Poisoning (prevention & control)
• Chemical and Drug Induced Liver Injury (prevention & control)
• Cytochrome P-450 Enzyme System (metabolism)
• Lipid Peroxidation (drug effects)
• Male
• Mice
• Microsomes, Liver (drug effects)
• Thioacetamide