Prophylactic efficacy of buparvaquone in experimentally induced Theileria annulata infection in calves.

Abstract

The antitheilerial activity of buparvaquone (BW 720C) was evaluated in experimentally induced Theileria annulata infections in cross-bred male calves. T. annulata infections were induced by injecting a suspension of infected ground tick tissue suspension (GUTTS) equivalent to two ticks subcutaneously into each calf. Buparvaquone at a dose of 2.5 mg kg-1 body weight was given as a single injection (intramuscularly) on Day 0 (Group 1), Day 8 (Group 2) and Day 12 (Group 3) post-infection. The animals in Groups 4 and 5 were untreated and challenged controls, respectively. All of the recovered animals from Groups 1-4 were challenged with a lethal dose of T. annulata at 6 weeks post-infection. The immunized animals were resistant to the homologous challenge, which killed three of four control animals (Group 5); the controls showed typical antemortem and post-mortem lesions of theileriosis.

• Authors: G C Bansal, N N Sharma
• Journal: Veterinary parasitology (Vet Parasitol) Vol. 33 Issue 3-4 Pg. 219-24 (Oct 1989) ISSN: 0304-4017 [Print] Netherlands
• PMID: 2815531 (Publication Type: Journal Article)

Chemical References

• Antiprotozoal Agents
• Naphthoquinones
• buparvaquone

Topics

• Animals
• Antiprotozoal Agents (therapeutic use)
• Cattle
• Male
• Naphthoquinones (therapeutic use)
• Random Allocation
• Theileriasis (drug therapy, prevention & control)