Toxicity and metabolism of a new insect repellent N,N-diethylphenylacetamide in mice, rats and guinea pigs on cutaneous application.

Abstract

Cutaneous LD50 of N,N-diethylphenylacetamide (DEPA), a new multi insect repellent was 2200, 3200 and 7100 mg/kg body weight in female mice, rats and guinea pigs; and 1600 and 4000 mg/kg in male mice and rats indicating a high degree of safety on skin contact. Dermal application of DEPA to young growing rats for 21 days at a dose of 50 mg/kg did not exert any adverse effects while massive doses of 500 and 1000 mg/kg caused marked reduction of body weight gain and lowering of activities of serum alanine aminotransferase, aspartate aminotransferase and cholinesterase. Along with DEPA, N-ethylphenylacetamide, phenylacetamide and phenylacetic acid were detected in the urine of DEPA treated mice, rats and guinea pigs.

• Authors: S S Rao, R V Swamy, P K Ramachandran
• Journal: Toxicology (Toxicology) Vol. 58 Issue 1 Pg. 81-9 (Sep 1989) ISSN: 0300-483X [Print] Ireland
• PMID: 2815093 (Publication Type: Journal Article)

Chemical References

• Acetamides
• Acetanilides
• Insect Repellents
• Aspartate Aminotransferases
• Alanine Transaminase
• Cholinesterases
• N,N-diethylphenylacetamide

Topics

• Acetamides (administration & dosage, metabolism, toxicity)
• Acetanilides (urine)
• Administration, Topical
• Alanine Transaminase (blood)
• Animals
• Aspartate Aminotransferases (blood)
• Cholinesterases (blood)
• Female
• Guinea Pigs
• Insect Repellents (toxicity)
• Lethal Dose 50
• Male
• Mice
• Models, Chemical
• Rats