Targeting peptide functionalized liposomes towards aminopeptidase N for precise tumor diagnosis and therapy.

Abstract

Aminopeptidase N (APN/CD13) is closely related to the growth of cancers and is suggested as a suitable target for anti-cancer therapy. Based on the "one-bead-one-compound" (OBOC) approach on a microarray device, we screened out a novel affinity peptide LN (YEVGHRC). It was determined that LN could specifically recognize and bind to APN. Moreover, LN-functionalized liposomes (LN-LS) could achieve efficient nano-encapsulated drug delivery under APN-overexpressing tumor conditions in vitro and in vivo. We expect that LN-LS could provide a new strategy for APN-positive tumor diagnosis and therapy.

• Authors: Xiangqian Jia, Qiuju Han, Zihua Wang, Yixia Qian, Yunhong Jia, Weizhi Wang, Zhiyuan Hu
• Journal: Biomaterials science (Biomater Sci) Vol. 5 Issue 3 Pg. 417-421 (Feb 28 2017) ISSN: 2047-4849 [Electronic] England
• PMID: 28138675 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• Liposomes
• Peptides
• Doxorubicin
• CD13 Antigens

Topics

• Animals
• Antineoplastic Agents (administration & dosage, pharmacokinetics, therapeutic use)
• CD13 Antigens (metabolism)
• Cell Line, Tumor
• Doxorubicin (administration & dosage, pharmacokinetics, therapeutic use)
• Drug Delivery Systems (methods)
• Hep G2 Cells
• Humans
• Liposomes (chemistry, metabolism)
• Mice, Nude
• Neoplasms (drug therapy, metabolism, pathology)
• Peptides (chemistry, metabolism)
• Protein Binding