Efficacy and safety of topical calcipotriol in management of alopecia areata: A pilot study.

Abstract

Reports have highlighted serum vitamin D deficiency and reduced 1,25-dihydroxyvitamin D(3) receptors(VDR) expression on hair follicles of alopecia areata(AA) patients. Very few studies have demonstrated efficacy of topical calcipotriol (vitamin D analogue) in AA. We intended to study the efficacy of calcipotriol lotion 0.005% in AA and correlate its outcome with serum vitamin D levels. We conducted a prospective study, in which 22 patients with AA were treated with calcipotriol lotion 0.005% twice daily for 3 months. Clinico-epidemiological parameters including severity of AA and SALT score were calculated at baseline and at 12 weeks. Hair regrowth was assessed monthly at 4, 8, 12 weeks. Serum vitamin D levels were measured at baseline. After 12 weeks of treatment, hair regrowth was observed in 13 (59.1%) patients. Mean period for onset of disease stabilization and hair regrowth was 4 weeks and 4.21± 2.13 weeks, respectively. Among these 13 patients, SALT50 and SALT100 was observed in 6(46.2%) and 2(9%) patients, respectively. Response to treatment was better in patients with lower vitamin D levels (p < .009). Topical calcipotriol can be an alternative treatment in AA and it could prove to be more useful in patients who are vitamin D deficient.

• Authors: Tarun Narang, Manju Daroach, M Sendhil Kumaran
• Journal: Dermatologic therapy (Dermatol Ther) Vol. 30 Issue 3 (May 2017) ISSN: 1529-8019 [Electronic] United States
• PMID: 28133875 (Publication Type: Journal Article)
• Copyright: © 2016 Wiley Periodicals, Inc.

Chemical References

• Dermatologic Agents
• Vitamin D
• calcipotriene
• Calcitriol

Topics

• Administration, Topical
• Adult
• Alopecia Areata (drug therapy, pathology)
• Calcitriol (administration & dosage, adverse effects, analogs & derivatives)
• Dermatologic Agents (administration & dosage, adverse effects)
• Female
• Hair (growth & development)
• Humans
• Male
• Pilot Projects
• Prospective Studies
• Severity of Illness Index
• Time Factors
• Treatment Outcome
• Vitamin D (blood)
• Young Adult