Saturated Fat Consumption and Risk of Coronary Heart Disease and Ischemic Stroke: A Science Update.

Abstract

At a workshop to update the science linking saturated fatty acid (SAFA) consumption with the risk of coronary heart disease (CHD) and ischemic stroke, invited participants presented data on the consumption and bioavailability of SAFA and their functions in the body and food technology. Epidemiological methods and outcomes were related to the association between SAFA consumption and disease events and mortality. Participants reviewed the effects of SAFA on CHD, causal risk factors, and surrogate risk markers. Higher intakes of SAFA were not associated with higher risks of CHD or stroke apparently, but studies did not take macronutrient replacement into account. Replacing SAFA by cis-polyunsaturated fatty acids was associated with significant CHD risk reduction, which was confirmed by randomized controlled trials. SAFA reduction had little direct effect on stroke risk. Cohort studies suggest that the food matrix and source of SAFA have important health effects.

• Authors: Joyce A Nettleton, Ingeborg A Brouwer, Johanna M Geleijnse, Gerard Hornstra
• Journal: Annals of nutrition & metabolism (Ann Nutr Metab) Vol. 70 Issue 1 Pg. 26-33 ( 2017) ISSN: 1421-9697 [Electronic] Switzerland
• PMID: 28125802 (Publication Type: Congress)
• Copyright: © 2017 The Author(s) Published by S. Karger AG, Basel.

Chemical References

• Fatty Acids

Topics

• Coronary Disease (etiology, prevention & control)
• Diet, Fat-Restricted
• Fatty Acids (administration & dosage, adverse effects)
• Humans
• Randomized Controlled Trials as Topic
• Risk Factors
• Stroke (etiology, prevention & control)