Spinal Cord Stimulation for Vegetative State and Minimally Conscious State: Changes in Consciousness Level and Motor Function.

Abstract

Twenty-one vegetative state (VS) patients and 10 minimally conscious state (MCS) patients were treated by spinal cord stimulation (SCS) following an electrophysiological evaluation 3 months or more after the onset of brain injury.A flexible four-contact cylindrical electrode was inserted into the epidural space of the cervical vertebrae, and placed at cervical levels C2-C4. Five-hertz stimulation was applied for 5 min every 30 min during the daytime at an intensity that produced muscle twitches of the upper extremities.Both the fifth wave in the auditory brainstem response (ABR) and N20 in the somatosensory evoked potential (SEP) were detected in 8 of the 21 VS patients and 9 of the 10 MCS patients. Of the 3 VS patients and 7 MCS patients who recovered following SCS therapy, all showed a preserved fifth wave in the ABR and N20 in the SEP, and all had received SCS therapy within 9 months after the onset of brain injury. Although the 3 patients who recovered from VS remained in a bedridden state, all 7 patients who recovered from MCS were able to emerge from the bedridden state within 12 months after the start of SCS.Five-hertz cervical SCS caused increased cerebral blood flow (CBF) and induced muscle twitches of the upper extremities, and MCS patients showed a remarkable recovery of consciousness and motor function in the upper extremities compared with the lower extremities. This SCS method could be a new neuromodulation and neurorehabilitation technique, and MCS patients may be good candidates for SCS therapy.

• Authors: Takamitsu Yamamoto, Mitsuru Watanabe, Toshiki Obuchi, Kazutaka Kobayashi, Hideki Oshima, Chikashi Fukaya, Atsuo Yoshino
• Journal: Acta neurochirurgica. Supplement (Acta Neurochir Suppl) Vol. 124 Pg. 37-42 ( 2017) ISSN: 0065-1419 [Print] Austria
• PMID: 28120050 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Adolescent
• Adult
• Aged
• Brain (blood supply)
• Cerebrovascular Circulation
• Evoked Potentials, Auditory, Brain Stem (physiology)
• Evoked Potentials, Somatosensory (physiology)
• Female
• Humans
• Male
• Middle Aged
• Muscle, Skeletal (innervation)
• Persistent Vegetative State (physiopathology, rehabilitation)
• Spinal Cord Stimulation
• Tomography, Emission-Computed, Single-Photon
• Treatment Outcome
• Young Adult