Caprolactam and benzoin: tests for induction of chromosome aberrations and SCEs in mouse bone marrow.

Abstract

CAP and ZOIN were tested in vivo for their ability to induce sister-chromatid exchanges (SCE) and chromosome aberrations in mouse bone marrow cells. Single intraperitoneal injections of ZOIN to a maximum of 3000 mg/kg body weight failed to increase the number of SCEs in metaphases recovered 24 h post-treatment, and doses of 1500 mg/kg did not induce measurable increases in chromosome-aberration levels among first-division metaphases at 18 h. Similarly, neither endpoint showed a significant increase following near-lethal doses of 700 mg/kg of CAP. Two lower doses of each chemical were also ineffective. Under the in vivo conditions of our test system, both chemicals were cytogenetically inactive.

• Authors: A F McFee, K W Lowe
• Journal: Mutation research (Mutat Res) Vol. 224 Issue 3 Pg. 347-50 (Nov 1989) ISSN: 0027-5107 [Print] Netherlands
• PMID: 2811923 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Azepines
• Mutagens
• Caprolactam
• Benzoin

Topics

• Animals
• Azepines (toxicity)
• Benzoin (toxicity)
• Bone Marrow (drug effects)
• Caprolactam (toxicity)
• Chromosome Aberrations
• Male
• Mice
• Mutagens
• Sister Chromatid Exchange (drug effects)