Abstract |
The chemical caprolactam (CAP) was tested for induction of chromosomal aberrations in bone marrow of male and female 1C3F1 mice at a single dose of 1000 mg/kg by oral intubation of an aqueous solution at a volume of 0.1 ml/10 g of body weight. Bone marrow was sampled from groups of 10 animals 24, 30 and 48 h after treatment. CAP did not produce chromosomal aberrations under the present experimental conditions. At the same time, benzo[a]pyrene, used as a positive control, significantly increased the aberration rates at a dose of 63 mg/kg.
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Authors | I D Adler, I Ingwersen |
Journal | Mutation research
(Mutat Res)
Vol. 224
Issue 3
Pg. 343-5
(Nov 1989)
ISSN: 0027-5107 [Print] Netherlands |
PMID | 2811922
(Publication Type: Journal Article)
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Chemical References |
- Azepines
- Mutagens
- Benzo(a)pyrene
- Caprolactam
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Topics |
- Animals
- Azepines
(toxicity)
- Benzo(a)pyrene
(toxicity)
- Bone Marrow
(drug effects)
- Caprolactam
(toxicity)
- Chromosome Aberrations
- Female
- Male
- Mice
- Mutagens
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