The intrinsic and interactive effects of RO 15-4513 and ethanol on locomotor activity, body temperature, and blood glucose concentration.

Abstract

The ability of the putative ethanol antagonist RO 15-4513 to antagonize ethanol - induced hypoactivity, hypothermia and hyperglycemia was investigated in rats. Although RO 15-4513 produced hypoactivity by itself, it attenuated ethanol - induced hypoactivity. This antagonism suggests that ethanol - induced hypoactivity is mediated by the GABA-benzodiazepine receptor complex which is thought to be the site of action of RO 15-4513. In contrast, although RO 15-4513 produced hypothermia by itself, it had no significant effect on ethanol - induced hypothermia. This suggests that the hypothermic effect of ethanol is not mediated by the GABA-benzodiazepine receptor complex. The fact that RO 15-4513, ethanol and the vehicle all produced hyperglycemia suggests a common stress effect and does not permit any firm conclusions to be drawn as to the interaction between ethanol and RO 15-4513 in modulating glycemic responses. These data indicate that the ethanol antagonism of RO 15-4513 is primarily confined to ethanol's behavioural effects and that ethanol's behavioural and physiological effects are mediated by neurochemically distinct mechanisms.

• Authors: A L Wood, P A Healey, J A Menéndez, S L Verne, D M Atrens
• Journal: Life sciences (Life Sci) Vol. 45 Issue 16 Pg. 1467-73 ( 1989) ISSN: 0024-3205 [Print] Netherlands
• PMID: 2811603 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Azides
• Blood Glucose
• Benzodiazepines
• Ethanol
• Ro 15-4513

Topics

• Analysis of Variance
• Animals
• Azides (pharmacology)
• Benzodiazepines (pharmacology)
• Blood Glucose (metabolism)
• Body Temperature (drug effects)
• Ethanol (antagonists & inhibitors, pharmacology)
• Male
• Motor Activity (drug effects)
• Random Allocation
• Rats
• Rats, Inbred Strains
• Time Factors