Wear particles released from
prosthetic implants can cause periprosthetic
osteolysis, a major cause of implant loosening. The aim of this study was to investigate the effects of the 11R-VIVIT
peptide on
osteolysis induced by
titanium (Ti) particles in vivo. Twenty-four C57BL/J6 mice were divided into 3 groups:
sham operation, Ti group, and Ti/VIVIT group. A calvarial
osteolysis model was established by implanting Ti particles into mouse calvaria of the Ti and Ti/VIVIT groups. After 2 weeks, 11R-VIVIT
peptide (10 mg/kg/day) was intraperitoneally injected into the mice of the Ti/VIVIT group for 14 days. The other 2 groups received saline injection. The calvarial specimens were removed and stained with van Geison staining. The calvarial sagittal
suture area was measured to observe
bone resorption. The calvarial new bone area was measured to observe bone formation. Compared with the
sham group, the area of calvarial new bone and calvarial sagittal
suture were higher in the Ti group (Pā<ā0.01). Compared with the Ti group, the area of calvarial new bone was higher and the area of calvarial sagittal
suture was lower in the Ti/VIVIT group (Pā<ā0.01). In conclusion, the 11R-VIVIT
peptide inhibited
bone resorption and enhanced bone formation. This may have contributed to lower wear particle-induced
osteolysis. This method could eventually be used to prevent
prosthesis loosening after
joint replacement and to prolong the life of the
prosthesis.