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Circular BANP, an upregulated circular RNA that modulates cell proliferation in colorectal cancer.

Abstract
Circular RNAs (circRNAs) are recently identified as widespread and diverse endogenous noncoding RNAs that may harbor vital functions in human and animals. However, the role of circRNAs in the process of tumorigenesis and development of colorectal cancer (CRC) remains vague. Here we characterized the circRNA expression profile from three paired CRC cancerous and adjacent normal tissues by human circRNA array, and identified 136 significantly overexpressed circRNAs and 243 downregulated circRNAs in CRC cancerous tissues (>2-fold changes). We further validated one circRNA generated from Exon 5-11 of BANP gene, termed circ-BANP. In addition, RT-PCR result showed that circ-BANP was overexpressed in 35 CRC cancerous tissues. Knockdown of circ-BANP with siRNA significantly attenuate the proliferation of CRC cells. In summary, our findings demonstrated that dysregulated circ-BANP appears to have an important role in CRC cells and could serve as a prognostic and therapeutic marker for CRC.
AuthorsMingchen Zhu, Yijun Xu, Yun Chen, Feng Yan
JournalBiomedicine & pharmacotherapy = Biomedecine & pharmacotherapie (Biomed Pharmacother) Vol. 88 Pg. 138-144 (Apr 2017) ISSN: 1950-6007 [Electronic] France
PMID28103507 (Publication Type: Journal Article)
CopyrightCopyright © 2016 Elsevier Masson SAS. All rights reserved.
Chemical References
  • BANP protein, human
  • Cell Cycle Proteins
  • DNA-Binding Proteins
  • Nuclear Proteins
  • RNA, Circular
  • RNA, Messenger
  • RNA
Topics
  • Base Sequence
  • Cell Cycle Proteins (genetics)
  • Cell Proliferation
  • Colorectal Neoplasms (genetics, pathology)
  • DNA-Binding Proteins (genetics)
  • Female
  • Gene Expression Profiling
  • Gene Expression Regulation, Neoplastic
  • HCT116 Cells
  • HT29 Cells
  • Humans
  • Male
  • Middle Aged
  • Nuclear Proteins (genetics)
  • RNA (genetics, metabolism)
  • RNA, Circular
  • RNA, Messenger (genetics, metabolism)
  • Reproducibility of Results
  • Up-Regulation (genetics)

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